Synthetic biological intelligent biomaterials for tissue regeneration and repair

Regenerative medicine is a transformative approach to healthcare that aims to repair or replace damaged tissues and organs to restore normal function. Synthetic biology is revolutionizing the field of regenerative medicine by enabling the creation of smart biomaterials that not only support tissue regeneration but also actively participate in tissue repair and regeneration. These materials are characterized by ease of development, excellent biosafety and the ability to respond to stimuli at target sites, which have enormous potential in applications such as connective tissue repair, bone regeneration and the treatment of complex conditions such as diabetic foot ulcers. Additionally, the integration of advanced manufacturing technologies such as 3D and 4D printing with these smart materials further enhances their effectiveness, enabling the creation of anatomically accurate and functionally dynamic designs.

Despite significant advances in the field of smart biomaterials, the ultimate goal of precise on-demand tissue regeneration has remained a challenge in the field. One of the key issues is the development of materials that can accurately mimic the complex biological environment of various tissues, as well as be adaptable to the dynamic conditions of the human body. The purpose of this research topic is to explore innovative approaches to the development, production and application of smart biomaterials in regenerative medicine. Recent advances in synthetic biology have stimulated the development of various polymer-based biotechnological materials, such as protein coatings and ECM-like hydrogels. Notably, synthetic biology allows biological systems to be programmed at the genetic level, offering promising opportunities for creating hybrid living materials that can respond to environmental stimuli. Additionally, the development of stimulus-responsive materials that change properties in response to specific triggers could lead to more effective and personalized treatments. By addressing these challenges, this Research Topic aims to advance the field of next-generation biomaterials that have the potential to revolutionize tissue and organ regeneration.

This research topic invites participants studying the design, development, and application of smart biomaterials in regenerative medicine. We welcome applications on the following topics: the use of synthetic biology in materials design, the development of hybrid living materials, the creation of stimuli-responsive materials and the application of these materials for connective tissue repair, organ regeneration, bone regeneration and the treatment of other complex clinical conditions such as diabetic foot ulcers and inflammatory bowel diseases (IBD). We encourage a variety of types of manuscripts, including original research articles, reviews, case studies, and perspectives that provide new insights or challenge existing paradigms. Submissions should focus on innovative strategies that address current limitations and suggest new directions for the use of smart biomaterials in preclinical settings.

Keywords: Smart biomaterials, Synthetic biology, Regenerative medicine, Living therapy, Tissue regeneration.

Important Note: All contributions to this research topic must fall within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to redirect an out-of-scope manuscript to a more appropriate section or journal at any stage of review.

Regenerative medicine is a transformative approach to healthcare that aims to repair or replace damaged tissues and organs to restore normal function. Synthetic biology is revolutionizing the field of regenerative medicine by enabling the creation of smart biomaterials that not only support tissue regeneration but also actively participate in tissue repair and regeneration. These materials are characterized by ease of development, excellent biosafety and the ability to respond to stimuli at target sites, which have enormous potential in applications such as connective tissue repair, bone regeneration and the treatment of complex conditions such as diabetic foot ulcers. Additionally, the integration of advanced manufacturing technologies such as 3D and 4D printing with these smart materials further enhances their effectiveness, enabling the creation of anatomically accurate and functionally dynamic designs.

Despite significant advances in the field of smart biomaterials, the ultimate goal of precise on-demand tissue regeneration has remained a challenge in the field. One of the key issues is the development of materials that can accurately mimic the complex biological environment of various tissues, as well as be adaptable to the dynamic conditions of the human body. The purpose of this research topic is to explore innovative approaches to the development, production and application of smart biomaterials in regenerative medicine. Recent advances in synthetic biology have stimulated the development of various polymer-based biotechnological materials, such as protein coatings and ECM-like hydrogels. Notably, synthetic biology allows biological systems to be programmed at the genetic level, offering promising opportunities for creating hybrid living materials that can respond to environmental stimuli. Additionally, the development of stimulus-responsive materials that change properties in response to specific triggers could lead to more effective and personalized treatments. By addressing these challenges, this Research Topic aims to advance the field of next-generation biomaterials that have the potential to revolutionize tissue and organ regeneration.

This research topic invites participants studying the design, development, and application of smart biomaterials in regenerative medicine. We welcome applications on the following topics: the use of synthetic biology in materials design, the development of hybrid living materials, the creation of stimuli-responsive materials and the application of these materials for connective tissue repair, organ regeneration, bone regeneration and the treatment of other complex clinical conditions such as diabetic foot ulcers and inflammatory bowel diseases (IBD). We encourage a variety of types of manuscripts, including original research articles, reviews, case studies, and perspectives that provide new insights or challenge existing paradigms. Submissions should focus on innovative strategies that address current limitations and suggest new directions for the use of smart biomaterials in preclinical settings.

Keywords: Smart biomaterials, Synthetic biology, Regenerative medicine, Living therapy, Tissue regeneration.

Important Note: All contributions to this research topic must fall within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to redirect an out-of-scope manuscript to a more appropriate section or journal at any stage of review.